Record-breaker Danny Care and Jonathan Joseph have both been recalled to England's back division for their Six Nations clash with Wales at Twickenham on Saturday.
Care will become England's most capped scrum-half when he makes his 78th Red Rose appearance to move past 2003 Rugby World Cup winner Matt Dawson.
Meanwhile Joseph starts at outside centre in the only other change to the starting XV that kicked off England's Six Nations title defence with a 46-15 win away to Italy last weekend.
England coach Eddie Jones was forced into making at least one change after first-choice scrum-half Ben Youngs went off after just 10 minutes at Rome's Stadio Olimpico with a knee injury that has ended his involvement in the Six Nations.
Care came off the bench to play in the rest of the match.
Meanwhile Joseph, a classic running centre, came in for Ben Te'o after the powerful Worcester midfielder impressed against Italy.
Earlier this week, Saracens star Richard Wigglesworth was called into the squad and he filled the vacancy on the bench left by Care's promotion in the matchday 23 announced by Jones on Thursday.
TEAM
England team to face Wales
1. Mako Vunipola
2. Dylan Hartley
3. Dan Cole
4. Joe Launchbury
5. Maro Itoje
6. Courtney Lawes
7. Chris Robshaw
8. Sam Simmonds
9. Danny Care
10. George Ford
11. Jonny May
12. Owen Farrell
13. Jonathan Joseph
14. Anthony Watson
15. Mike Brown
Reserves
16. Jamie George
17. Alec Hepburn
18. Harry Williams
19. George Kruis
20. Sam Underhill
21. Richard Wigglesworth
22. Ben Te'o
23. Jack Nowell
