The Wallabies have confirmed flyhalf Carter Gordon and lock Nick Frost will not feature again at the Rugby World Cup after sustaining knee injuries.
The side is hanging onto their World Cup dream, needing Portugal to win by eight or more points against Fiji.
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However, if they do qualify, they will be without their star duo after they picked up knocks over the past week.
Gordon was a late withdrawal from their final pool game against Portugal, with scans revealing a knee cartilage injury
As for Frost, he suffered a right knee joint injury during the 36-16 win in Saint Etienne.
Both will return to Australia in order to continue rehabilitation ahead of next year's Super Rugby Pacific season.
They join Max Jorgensen on the sidelines, who was ruled out last month after a fractured fibula.
“We’re disappointed for Nick and Carter that their seasons have ended through injury," Wallabies coach Eddie Jones said in a statement.
“Nick showed great courage to play through significant discomfort against Portugal, while Carter has earned valuable experience during his first year as a Test player.
“We wish both of them a quick and successful recovery and to watching them continue to improve during Super Rugby Pacific next year.”
The Wallabies confirmed they will announce medical replacements 'in due course', likely awaiting the results of Monday's (AEST) match between Portugal and Fiji.
Jones also confirmed after last week's match that Will Skelton and Taniela Tupou would likely be available for next week if they qualify.