The Queensland Reds' top two hopes have been dealt a massive blow with backrower Harry Wilson set to be sidelined for six weeks.
Wilson will miss Saturday's blockbuster against the ACT Brumbies after fracturing his arm in contact with the Chiefs in Hamilton.
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The number eight will be pushing to return for the last fortnight of the regular season, with the Reds currently sitting in third.
It's a double blow for the Reds, with Filipo Daugunu managing a lower limb injury.
The injuries mean Joe Brial retains his spot in the back-row at number eight, with Seru Uru returning to blindside flanker.
“We saw how Joe Brial stepped up in the backrow against the Chiefs with his best performance for the Reds and he will get to show his wares at No.8 against the Brumbies,” coach Les Kiss said.
Tim Ryan returns on the wing, with Sef Fa'agase and Tom Lynagh back in the starting side.
For the ACT Brumbies, Tuaina Taii Tualima and Ryan Lonergan come into the side, with the club fresh off the bye.
In further changes, Rob Valetini shifts to blindside flanker and Tom Hooper into the second row.
The game will be filled with milestones, with Reds captain Tate McDermott and Brumbies winger Andy Muirhead set to play their 100th games for their respective sides.
“Andy is a consummate professional who gives his all day in, day out for the Brumbies. He deserves recognition for reaching this milestone, it’s an incredible achievement,” coach Stephen Larkham said.
“He will come full circle this Saturday in reaching 100 caps in the place where he grew up and I’m sure he will have plenty of family and friends there cheering him on. The rest of the playing group will give their all to try to make it a memorable occasion for him.
“The bye week last week was welcomed, it’s given us a chance to recover and get our ducks in a row for the second half of the season. All Australian teams have been in great form this season, including the Reds, and we’re looking forward to taking them on."
REDS (1-15): Sef Fa'agase, Matt Faessler, Zane Nonggorr, Josh Canham, Lukhan Salakaia-Loto, Seru Uru, Fraser McReight, Joe Brial, Tate McDermott (c), Tom Lynagh, Tim Ryan, Hunter Paisami, Dre Pakeho, Lachie Anderson, Heremaia Murray
Replacements: Richie Asaita, Alex Hodgman, Jeffery Toomana-Allen, Angus Blyth, John Bryant, Kalani Thomas, Harry McLaughlin-Phillips, Jock Campbell
BRUMBIES (1-15): James Slipper, Billy Pollard, Allan Alaalatoa (c), Nick Frost, Tom Hooper, Rob Valetini, Rory Scott, Tuaina Taii Tualima, Ryan Lonergan, Noah Lolesio, Corey Toole, David Feliuai, Len Ikitau, Andy Muirhead, Tom Wright
Replacements: Lachlan Lonergan, Blake Schoupp, Feao Fotuaika, Lachlan Shaw, Luke Reimer, Harrison Goddard, Declan Meredith, Ollie Sapsford
