With finals only two weeks away, every Super W game in round five will play a significant role in determining who will qualify.
There is no more important game so far in 2022 than the Fijiana Drua welcoming the NSW Waratahs to the Gold Coast, with the winner all but securing their spot in the Final.
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This is followed on Saturday by the Reds taking on the Melbourne Rebels, with a win cementing Queensland's spot in the final.
The round finishes at Viking Park as the Brumbies look to keep their finals hopes alive as they face the Western Force.
Check out all the details for the Super W teams for round three:
Friday 1 April 4:05 pm AEDT – Fijiana Drua v NSW Waratahs at CBUS Super Stadium, ad-free, live and on demand on Stan Sport
The Drua are looking to continue their strong start to the season, making a number of changes for Friday's blockbuster.
Sereima Leweniqila shifts to second row, allowing Ema Adivitaloga to come into the backrow.
Rusila Tamoi partners Merewalesi Rokouono in the halves as Rejieli Uluinayau pushes back to the bench.
Roela Radiniyavuni comes into the centres, with Kolora Lomani and Vitalina Naikore swapping wings
Waratahs coach Campbell Aitken has made three changes to the starting team that defeated the Rebels, headlined by the return of Wallaroo Arabella McKenzie.
McKenzie is a welcome addition after completing her commitments with Super Rugby Aupiki, replacing Mahalia Murphy (hamstring) at fullback.
Sera Naiqama makes her first run-on start of the season in place of the injured Atasi Lafai (shoulder) and joins Kaitlan Leaney in the second row.
Meanwhile, Iliseva Batibasaga and Lori Cramer return to the starting side, with Tatum Bird dropping back to the bench after the scrumhalf scored a double on the wing.
FIJIANA (1-15): Joma Rubuti, Vika Matarugu, Bitila Tawake (c), Sereima Leweniqila, Merevesi Ofakimalino, Teresia Tinanivalu, Ema Adivitaloga, Karalaini Naisewa, Rusila Tamoi, Merewalesi Rokouono, Vitalina Naikore, Roela Radiniyavuni, Raijieli Laqeretabua, Kolora Lomani, Timaima Ravisa
RESERVES: Ro Silo Togotogorua, Mereoni Naositava, Akosita Ravato, Doreen Narokete, Adi Unaisi Biau, Rejieli Uluinayau, Vive Sikisawana, Younis Finau Karavaki Bese
WARATAHS (1-15): Emily Robinson, Adiana Talakai, Bridie O'Gorman, Kaitlan Leaney, Sera Naiqama, Piper Duck, Emily Chancellor, Grace Hamilton (c), Illiseva Batibasaga, Pauline Piliae, Lori Cramer, Katrina Baker, Georgina Friedrichs, Margot Vella, Arabella McKenzie
RESERVES: Faliki Pohiva, Natalie Delamere, Eva Karpani, Sabine Blakeman, Ana-Lise Sio, Tatum Bird, Nicole Nathan, Layne Morgan
Saturday 2 April 5:15 pm AEDT – Queensland Reds v Melbourne Rebels at Suncorp Stadium, ad-free, live and on demand on Stan Sport and Nine Network
Reds head coach Simon Craig has made two changes to the starting side as they prepare for the Rebels.
Alapeta Ngauamo makes her return from injury, partnering Tasmin Sheppard and Liz Patu in the front row.
Caity Costello earns a recall to the starting side, which shifts Melanie Wilks in the centres and Malaela Su'a to the bench.
Su'a is joined by the bench by Wallaroo squad member Tiarna Molloy, who is in line for her first appearance of 2022 as she returns from injury.
The Rebels have named Tiarah Minns to start as part of seven changes to their line-up.
Minns returns after a lower leg injury and comes back into the second row with Nawel Remini.
Kirsty Matapa comes onto the wing, pushing Tyra Boysen to inside centre alongside Hope Schuster.
Sarah Hogan will make her first start at full-back for the club, while Allysaa Lolesio-Pua has been promoted to left-wing.
REDS (1-15): Alapeta Ngauamo, Tasmin Sheppard, Liz Patu, Aleena Greenhalgh, Annabelle Codey, Kiri Longman, Shannon Parry (c), Sophie Holyman, Sarah Lewis, Renae Nona, Ivania Wong, Cecilia Smith, Melanie Wilks, Caity Costello, Ellie Draper
RESERVES: Tiarna Molloy, Madi Schuck, Theresa Soloai, Hana Lane, Okeroa Manihera, Imogen Hei, Malaela Su'a, Briana Dascombe
REBELS (1-15): Janita Kareta, Ashley Marsters, Eirenei Nani, Nawel Remini, Tiarah Minns, Michaela Maunsell, Mel Kawa (c), Willow Rowland, Georgia Cormick, Jade Te Aute, Allyssa Lolesio-Pua, Tyra Boysen, Hope Schuster, Kirsty Matapa, Sarah Hogan
RESERVES: Emily Harvey, Seiloga Taisi, Anome Mafaufau, Nuala O'Connor, Katie Bugden, Jessica Campbell, Claire Ryan, Kelera Ratu
Sunday 3 April 2:00 pm AEDT – Brumbies v Western Force at Viking Park, ad-free, live and on demand on Stan Sport
Brumbies coach Dan Hawke has made a number of changes, welcoming back WallarooMichaele Leonard.
Leonard, who along with McKenzie played in Super Rugby Aupiki, will make her return from the bench.
She is joined on the bench by Gabby Petersen, who makes a long-awaited return from a knee injury.
Niki Paterson has earned her first start at loosehead prop, joined by Harriet Elleman and Louise Burrows in the front-row
As for the Force, they have kept a settled side after their strong second-half against the Drua.
Shiane Kani comes to the starting front-row, coming into loosehead prop for Raewyn Tuheke.
Along with this, Mahalia Ellis partners Rebecca Clough in the second row as they hunt for their first win of 2022
BRUMBIES (1-15): Niki Peterson, Harriet Elleman, Louise Burrows, Ash Fernandez, Shellie Milward, Grace Kemp, Talei Qalo Wilson, Rebecca Smyth (c), Jay Huriwai, Ash Hewson, Biola Dawara, Siokapesi Palu, Mana Furuta, Jemima McCalman, Ella Ryan
RESERVES: Tania Naden, Onēata Schwalger, Makoto Lavemai, Michaela Leonard, Pearl Rakete, Gisela Vea, Gabby Petersen, Hailey Derera
FORCE (1-15): Shiane Kani, Hera-Barb Malcolm Heke, Sera Ah-Sam, Rebecca Clough, Mahalia Ellis, Keira Macaskill, Anneka Stephens, Tamika Jones, Kendra Fell, Nicole Ledington, Zakiya Kerepoa, Trilleen Pomare (c), Ariana Hira-Herangi, Aiysha Wigley, Turiti Galiki
RESERVES: Darryl Wickliffe, Raewyn Tuheke, Brooke Mason, Valuese Tiakia, Tui Cope, Libya Teepa, Hula Swannell, Madeline Putz