The Wallabies will be forced into a completely fresh line-up as they prepare to finish their Spring Tour against Wales.
The bad run of injuries in 2022 was amplified against Ireland, with six players already on their way home to Australia, the most serious being Taniela Tupou's Achilles injury.
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Along with this, overseas picks such as Bernard Foley and Will Skelton will return to their clubs given the game falls outside the International window.
As Dave Rennie put it after last week's defeat, the majority of these injuries have been contact-related incidents, reflecting the bad luck this side had gone through this year.
Rugby.com.au goes through the list as Rennie scrambles to field a team for Sunday morning's (AEDT) Test against Wales.
Starting XV
1.Angus Bell
Bell didn't go on the Spring Tour as he continues to recover from a toe injury.
The loosehead injured the plantar ligament in his big toe, which kept him out of the start of the Rugby Championship before ruling him out for the Spring Tour.
Bell is expected to return in time for the start of the Super Rugby Pacific season, with the Waratahs hopeful he will feature in pre-season trials.
2. Dave Porecki
Porecki suffered a concussion during last week's defeat to Ireland, replaced in the first half.
It's his second of the International period, ruled out of the first Test against Argentina after a training incident.
Porecki has established himself as the front-runner for next year's World Cup at the position, with discipline a key work-on for the hooker.
3. Taniela Tupou
Tupou is the most serious of the injured pack from Ireland, suffering a suspected ruptured Achilles.
The barnstorming Red collapsed trying to take a hit-up just minutes after coming onto the field.
He will be racing the clock to be fit for the World Cup if the worst fears are confirmed.
4. Matt Philip
Philip suffered an ACL injury just hours before the Wallabies were set to head overseas for the Spring Tour.
This came after missing the second Bledisloe due to a sternum injury.
The Rebel was one of the Wallabies' best in 2022 and will be looking to pick up where he left off when he eventually returns, likely sometime during Super Rugby Pacific.
5. Will Skelton
Skelton is unavailable as the fixture falls outside World Rugby's designated international period.
This means he will return to French club La Rochelle with his stocks raised after three positive performances, particularly against Italy and Ireland.
His involvement will likely depend on what happens with the overseas player laws, likely sitting behind Quade Cooper/Bernard Foley, Marika Koroibete and Samu Kerevi
6. Lachlan Swinton
Swinton hasn't been sighted in Australian Rugby since the opening match of Super Rugby Pacific, dealing with nerve damage in his shoulder.
The back-rower required a nerve transfer operation to regain muscle function after his shoulder was not responding to treatment.
The Waratahs remain hopeful he will be available for their round one match against the Brumbies
7. Rob Leota
Leota suffered a long-term Achilles injury during the first Bledisloe Test in Melbourne.
The Rebel was forced off during the opening half, undergoing surgery shortly after the incident.
He will likely return midway through the Super Rugby Pacific season.
8. Rob Valetini
Valetini will miss the final game of the season after an ankle injury.
Rennie and the Wallabies believe it is a syndesmosis injury, which will limit his pre-season involvement.
It is unlikely it will keep him out of any action in 2023, looking to build off an impressive season.
9. Nic White
White has been ruled out of the Wales Test in bizarre scenes.
The scrumhalf was initially cleared of concussion after passing his HIA, before his symptoms were upgraded to ‘criteria one’ assessment, based on “balance disturbance and ataxia”, meaning he must sit out for a minimum of 12 days.
The 32-year-old remains one of the premier scrumhalves in the country and will be a key figure for the Brumbies next season.
10. Quade Cooper
Cooper was a casualty of the Argentina tour, suffering a long-term Achilles injury.
It came after the flyhalf was a late withdrawal from the first Test of the year with a calf complaint.
He will return via the Japanese Top League One, looking to reclaim his place for the World Cup.
11. Andrew Kellaway
Kellaway looks to have sustained a fracture to his fifth metatarsal during last week's defeat to Ireland.
The Rebels standout has dealt with injury throughout the season, missing part of the England series with a hamstring complaint.
Kellaway has emerged as one of the key contenders for the back three, expected to spend time across the backline for the Rebels next year.
12. Samu Kerevi
Kerevi suffered a knee injury during the Commonwealth Games after making the switch to the seven-a-side format between the England and Argentina Tests.
It ruled him out for the rest of the season after he started the opening three games against England.
Kerevi will make his return via Japanese club Suntory and looms as a key piece of their attack.
13. Hunter Paisami
Paisami picked up a medial collateral ligament (MCL) injury in the first minutes of their loss to Ireland.
The centre missed some time during the Rugby Championship after picking up a concussion against South Africa in Sydney.
14. Marika Koroibete
Koroibete is back in Japan with Panasonic Wild Knights, not travelling with the Wallabies to Europe.
It is the second time the winger has missed the end-of-season tour as part of an agreement with his Japanese club.
Expect the winger back in Wallabies contention in 2023 after yet another stellar year.
15. Tom Banks
Banks has made an early exit from Wallaby camp after picking up an ankle injury.
It was initially expected to just keep him out of the Italy Test, however, scans revealed it was worse than first thought.
The departing Brumby heads to Japan with question marks surrounding his future under the overseas player laws.
Reserves
16. Alex Mafi
Mafi missed a fair chunk of the 2022 Super Rugby Pacific season with a neck injury.
The Rebels' new recruit will be eager to press his claims for a Wallabies call-up with the likes of Porecki, Fainga'a and Latu struggling with discipline in the past.
17. Harry Johnson-Holmes
Johnson-Holmes suffered a ruptured Achilles tendon in Wallabies camp ahead of the July Test series against England.
It came just months after the prop picked up an MCL injury during the Waratahs' upset victory over the Crusaders.
18. Pone Fa'amausili
Fa’amausili's bad luck with injury continued during Australia A after damaging his hamstring.
The Rebel has dealt with calf problems in the past and remains deadly on his day
19. Izack Rodda
Rodda has missed the entirety of the Wallabies international season with a foot injury.
The Force lock remains one of the best on his day, adding further competition to a very deep second-row department.
20. Josh Kemeny
Kemeny is another returning Rebel, missing the majority of the Super Rugby season with an ACL injury.
He made his return on the Rebels tour to Japan, looking to regain the form that saw the Sydney Uni product called into the Wallabies squad last year before the France series.
21. James O'Connor
O'Connor is continuing his comeback from an ankle injury suffered with Brisbane club Brothers.
The playmaker finds himself on the outer at the national level, although will rocket back into contention if he can recapture the MVP-calibre form from Super Rugby AU 2021
22. Bernard Foley
Foley is another unavailable under World Rugby's regulation nine, returning to Japan.
The former Waratah finds himself back on selectors' radars after earning inclusion for the first Bledisloe Test in Melbourne
23. Lalakai Foketi
Foketi injured his shin during the narrow loss to France.
The Waratah has had a breakout season in 2022, emerging as a key figure in the Wallabies midfield.
