Wales coach Warren Gatland said Tuesday that his weakened team must overcome the "fear factor" when they face world champions South Africa at Twickenham this weekend.
Injuries and player unavailability have limited Gatland's choices for Saturday's clash in London, which comes ahead of a two-Test tour to Australia.
Catch the Springboks take on Wales LIVE, ad-free and on demand on Stan Sport.
The latest blow came with flanker Jac Morgan ruled out of the Springboks clash as well as next month's Tests in Sydney and Melbourne.
Morgan, who was World Cup co-captain with Dewi Lake last year, missed this year's Six Nations because of a knee injury.
But he now has a hamstring problem that he suffered during Ospreys' United Rugby Championship quarter-final defeat against Munster earlier this month.
The Welsh Rugby Union announced on Tuesday that Morgan has been released from the squad.
Wales, 10th in the world rankings, are without several England-based players including Nick Tompkins, Dafydd Jenkins and Tommy Reffell because the game falls outside World Rugby's Test window.
And they have been badly hit in the second-row department, with Six Nations skipper Jenkins and his colleague at English Premiership club Exeter, Christ Tshiunza, both unavailable, Will Rowlands rested and Adam Beard injured.
South Africa are the "home" team on Saturday, with Twickenham their choice of venue, and Wales go into the game following six successive Test defeats.
"We have our backs to the wall a little bit this week, but we are really excited about the challenge," said Gatland.
"I see it as a great opportunity for other players to step up and put their hands up."
The New Zealander said taking on the best teams in the world was the way to improve.
"Test match rugby is tough and physical -- you have got to be able to handle adversity," he said. "You have to go through that pain sometimes and be able to come out the other side.
"There is nothing wrong with that. You have to be brave and overcome your fear factor.
"You are going out there and playing against big men, and it is going to hurt and you have to go through some pain."
Hooker Lake, who also sat out the Six Nations due to injury, will be captain against South Africa, with James Botham, grandson of England cricket great Ian Botham, lining up in a back-row that also includes Taine Plumtree and Aaron Wainwright.
Cardiff scrum-half Ellis Bevan is handed a Test debut, while Liam Williams makes a first Wales appearance since the 2023 World Cup.
There are three uncapped players on the bench -- Ospreys forward James Ratti, Scarlets centre Eddie James and Cardiff back Jacob Beetham.
As for the Springboks, flanker Pieter-Steph du Toit will captain understrength world champions South Africa after the 2019 and 2023 Rugby World Cup winner got the nod ahead of fellow forwards Bongi Mbonambi and Eben Etzebeth for the Springboks' first match since winning the World Cup in France last October.
Club commitments, injuries and a suspension left Erasmus with only 10 of the 2023 World Cup final squad to consider for the Twickenham Test.
He included seven in his starting line-up and the other three are on the bench. Erasmus also chose four uncapped players, with two set to start.
The starters from the 12-11 World Cup final victory over New Zealand include backs Jesse Kriel and Faf de Klerk and forwards Ox Nche, Etzebeth, Franco Mostert, Kwagga Smith and Du Toit.
Back Damian de Allende and forwards Mbonambi and Frans Malherbe are among the replacements as the Springboks seek a third straight victory over Wales.
Winger Edwill van der Merwe and fly-half Jordan Hendrikse are the new caps who will start, and back Sacha Feinberg-Mngomezulu and loose forward Ben-Jason Dixon could debut off the bench.
SPRINGBOKS (15-1): Aphelele Fassi; Edwill van der Merwe, Jesse Kriel, Andre Esterhuizen, Makazole Mapimpi; Jordan Hendrikse, Faf de Klerk; Evan Roos, Pieter-Steph du Toit (capt), Kwagga Smith; Franco Mostert, Eben Etzebeth; Vincent Koch, Malcolm Marx, Ox Nche
Replacements: Bongi Mbonambi, Ntuthuko Mchunu, Frans Malherbe, Salmaan Moerat, Ben-Jason Dixon, Grant Williams, Sacha Feinberg-Mngomezulu, Damian de Allende
WALES (15-1): Cameron Winnett; Liam Williams, Owen Watkin, Mason Grady, Rio Dyer; Sam Costelow, Ellis Bevan; Aaron Wainwright, James Botham, Taine Plumtree; Ben Carter, Matthew Screech; Henry Thomas, Dewi Lake (capt), Gareth Thomas
Replacements: Evan Lloyd, Kemsley Mathias, Keiron Keiron Assiratti, James Ratti, Mackenzie Martin, Gareth Davies, Eddie James, Jacob Beetham
